Immunopathogenesis and Treatment of Rheumatoid Arthritis: Recent Developments
نویسندگان
چکیده
منابع مشابه
Rheumatoid Arthritis: Early diagnosis and treatment outcomes
Rheumatoid arthritis (RA) is an inflammatory progressive disease which in the absence of appropriate treatment can lead to joint destruction and disability. Prognosis of RA may be predicted based on the presence of some clinical and laboratory evidences.New criteria for classification of RA provides opportunity for earlier treatment. Initiation of treatment particularly by combination of DMARDs...
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Progress into the understanding of immunopathology in rheumatoid arthritis is reviewed in the present article with regard to pro-inflammatory cytokine production, cell activation and recruitment, and osteoclastogenesis. Studies highlight the potential importance of T helper 17 cells and regulatory T cells in driving and suppressing inflammation in rheumatoid arthritis, respectively, and highlig...
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Rheumatoid arthritis (RA) is characterised by synovial tissue leucocyte ingress and angiogenesis, or new blood vessel growth. The disease is thought to occur as an immunological response to an as yet unidentified antigen. Even in early RA, some of the earliest histological observations are blood vessels. A mononuclear infiltrate characterises the synovial tissue along with a luxuriant vasculatu...
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974, Glass RJ et al.10 Key Point Patients treated with TNF inhibitors remain on therapy long term, suggesting durable effects and tolerability. Anti-TNF Therapy in Biologic-Naïve and Experienced Patients Clinical trials of anti-TNF therapy typically excluded patients who had prior exposure to a TNF inhibitor. In clinical practice, clinicians often encounter patients with RA who have been treate...
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PURPOSE OF REVIEW Treatment of rheumatoid arthritis (RA) requires strategies for treatment timing and treatment choices. To help rheumatologists choose the right treatment at the right time, this review describes recent trial outcomes, and studies into possible predictors for treatment strategy outcomes. RECENT FINDINGS Very early treatment with abatacept was clinically effective, but prevent...
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ژورنال
عنوان ژورنال: Bangladesh Journal of Medical Biochemistry
سال: 2015
ISSN: 2408-8331,2073-9915
DOI: 10.3329/bjmb.v7i2.22415